Search results for " abstinence"
showing 10 items of 13 documents
Emotional and autonomic dysregulation in abstinent alcoholic men: An idiosyncratic profile?
2019
Men who misuse alcohol tend to experience negative affect, which may entail difficulties in regulating emotions to cope effectively with stressful or anxiety-provoking situations, thus increasing the risk of alcohol relapse. This dysphoric state has been associated with alexithymia, which compromises an individual's abilities to acknowledge, recognize, and regulate emotional states. A physiological correlate of emotional regulation is autonomic flexibility, as shown by emotional dysregulation in men who misuse alcohol being correlated with reduced parasympathetic activation to control heart rate variability during stress and/or conflict situations. Hence, the main aim of this study was to i…
Group treatment for substance use disorder in adults: A systematic review and meta-analysis of randomized-controlled trials
2019
Abstract Background and aims From residential programs to outpatient services, group therapy permeates the clinical field of substance misuse. While several group interventions for substance use disorders (SUDs) have demonstrated effectiveness, the existing evidence on group therapy has not been systematically reviewed. The current meta-analysis aims to provide estimates of the efficacy of group therapy for SUDs in adults using rigorous methods. Methods We included studies comparing group psychotherapy to no treatment control groups, individual psychotherapy, medication, self-help groups, and other active treatments applying no specific psychotherapeutic techniques for patients with substan…
Dopamine restores limbic memory loss, dendritic spine structure, and NMDAR-dependent LTD in the nucleus accumbens of alcohol-withdrawn rats
2018
Alcohol abuse leads to aberrant forms of emotionally salient memory, i.e., limbic memory, that promote escalated alcohol consumption and relapse. Accordingly, activity-dependent structural abnormalities are likely to contribute to synaptic dysfunctions that occur from suddenly ceasing chronic alcohol consumption. Here we show that alcohol-dependent male rats fail to perform an emotional-learning task during abstinence but recover their functioning byl-3,4-dihydroxyphenylalanin (l-DOPA) administration during early withdrawal.l-DOPA also reverses the selective loss of dendritic “long thin” spines observed in medium spiny neurons of the nucleus accumbens (NAc) shell of alcohol-dependent rats d…
Controlled attenuation parameter and alcoholic hepatic steatosis: Diagnostic accuracy and role of alcohol detoxification.
2018
Background & Aims: Controlled attenuation parameter (CAP) is a novel non-invasive measure of hepatic steatosis, but it has not been evaluated in alcoholic liver disease. Therefore, we aimed to validate CAP for the assessment of biopsy-verified alcoholic steatosis and to study the effect of alcohol detoxification on CAP. Methods: This was a cross-sectional biopsy-controlled diagnostic study in four European liver centres. Consecutive alcohol-overusing patients underwent concomitant CAP, regular ultrasound, and liver biopsy. In addition, we measured CAP before and after admission for detoxification in a separate single-centre cohort. Results: A total of 562 patients were included in the s…
Urinary ethyl glucuronide (uEtG) as a marker for alcohol consumption in liver transplant candidates: a real-world cohort
2020
In order to reduce alcohol relapse after liver transplantation (LT), the German national guidelines for waiting-list maintenance and organ allocation demand a minimum 6-month period of alcohol abstinence pre-LT, confirmed by measuring urinary ethyl glucuronide (uEtG). Between January 2015 and June 2016, uEtG was measured at least once in 339 cirrhotic patients with an indication for LT at the University Medical Center Mainz. uEtG was measured with an enzyme-linked immunosorbent assay (ELISA) screening test (cutoff value: 500 µg/L). For uEtG values ≥ 500 µg/L, liquid chromatography-mass spectrometry (LC-MS/MS) was performed as a confirmatory assay. Data were collected prospectively in a tra…
Neuroimmune and Mu-Opioid Receptor Alterations in the Mesocorticolimbic System in a Sex-Dependent Inflammatory Pain-Induced Alcohol Relapse-Like Rat …
2021
Evidence concerning the role of alcohol-induced neuroinflammation in alcohol intake and relapse has increased in the last few years. It is also proven that mu-opioid receptors (MORs) mediate the reinforcing properties of alcohol and, interestingly, previous research suggests that neuroinflammation and MORs could be related. Our objective is to study neuroinflammatory states and microglial activation, together with adaptations on MOR expression in the mesocorticolimbic system (MCLS) during the abstinence and relapse phases. To do so, we have used a sex-dependent rat model of complete Freund’s adjuvant (CFA)-induced alcohol deprivation effect (ADE). Firstly, our results confirm that only CFA-…
Perfil cognitivo de los alcohólicos abstinentes durante un periodo de tiempo prolongado en comparación con un grupo de hombres que no consumen alcohol
2018
Scarce studies have focused on the cognitive profile of chronic alcoholic men after long-term abstinence. Thus, we examined neuropsychological differences between long-term abstinent alcoholics for an average of 3.2 years ( n = 40, LTAA; age = 45.55 ± 8.99) and matched for socio-demographic variables with non-alcoholic controls ( n = 39; age = 42.05 ± 11.33). To this aim, we employed a neuropsychological assessment battery covered relevant cognitive domains: IQ, memory, attention, executive functions and empathy. LTAA presented deficits in abstract reasoning, speed processing, sustained attention, working and long-term memory (verbal and visuospatial), cognitive flexibility, inhibition and …
Ramadan
2018
The contribution analyzes the Islamic holiday of Ramadan in its various aspects: its etymology, its chronology, popular customs and traditions, its theological and religious significance
ENTREACTO / ENTR?ACTE Un film / A Film Chopin y los Sand, amor a cuatro bandas. Aproximación a la esfera privada de Fryderyk Chopin a partir de la pe…
2021
Two centuries later, the legend Chopin-Sand continues to supply the collective imaginary with vague readings, where historical truthfulness, let alone musical truth, is often contingent on the literary. The much discussed and bellicose romance between the Polish composer and the French novelist, George Sand, tends to some reductionism and evades an obvious reality: Fryderyk Chopin meets George Sand when she was already the mother of two children. This circumstance suggests reformulating certain romantic stereotypes. Jerzy Antczak?s biographical film Pragnienie Mi?o?ci (Chopin: Desire for Love, 2002) does not overlook this detail and makes it one of its narrative axes. The relationship betwe…
Microbiome and Diseases: Hepatic Disorders
2018
Intensive research efforts aim to understand the multifaceted molecular mechanisms underlying disease onset and progression of nonalcoholic fatty liver disease (NAFLD) and alcohol-induced liver disease (ALD). Taken together, NAFLD and ALD are the most common liver diseases worldwide, and universally accepted therapies other than lifestyle interventions either focusing on weight reduction and physical exercise or alcohol abstinence are lacking. During the last decade, alterations of intestinal microbiota composition and intestinal barrier function leading to an increased translocation of bacterial endotoxin and of metabolites originating from an altered intestinal microbiome are emerging as …